DEVELOPMENT AND CHARACTERIZATION OF PH-RESPONSIVE POLYMERIC MICROBEADS INTERCALATED WITH MONTMORILLONITE FOR CONTROLLED RELEASE OF DOXORUBICIN

Objective: The aim of the present study is to develop pH-responsive polymeric microbeads for controlled release doxorubicin. Methods: Doxorubicin-encapsulated were developed by a simple ionotropic gelation method using sodium alginate, gum ghatti, and montmorillonite (MMT). In this work, we investigate positive benefits MMT mineral as drug carrier DOX. X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) used characterize generated microbeads. influence hetero-ionic concentration on encapsulation efficiency from was examined. vitro swelling studies performed at pH 2.0 7.4 37 °C. cytotoxicity studied in cultures human breast cancer cell line (MCF-7). Results: FTIR confirms generation also interaction between polymer matrix, DOX clay. XRD analysis reveals molecular dispersion presence matrix. SEM reveal are spherical shape with rough surfaces. Swelling dependent test medium, which may be favorable intestinal delivery. MTT results that showed good toxicity against MCF-7 cells. kinetics followed both higuchi korsmeyer-peppas models. Conclusion: findings suggest DOX-encapsulated promising carriers delivery applications. fabricated further needs warrant